Effects of mutations in the helix G region of horseradish peroxidase.

doi:10.1016/j.biochi.2008.05.008

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Article

Effects of mutations in the helix G region of horseradish peroxidase.

Biochimie - 1 Sept 2008

Ryan Barry J, O'Fágáin Ciarán

Abstract excerpt

Horseradish peroxidase (HRP) has long attracted intense research interest and is used in many biotechnological fields, including diagnostics, biosensors and biocatalysis. Enhancement of HRP catalytic activity and/or stability would further increase its usefulness. Based on prior art, we substituted solvent-exposed lysine and glutamic acid residues near the proximal helix G (Lys 232, 241; Glu 238, 239) and between...

Topics

Calcium
Enzyme Stability
Horseradish Peroxidase
Hydrogen Bonding
Mutation
Protein Structure, Secondary
Protein Structure, Tertiary
Recombinant Proteins
Temperature

Source

Open in PubMed

Identifiers

PMID: 18554516
DOI: 10.1016/j.biochi.2008.05.008

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