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Article

Successful amplification of degraded DNA for use with high-throughput SNP genotyping platforms.

Human mutation - 1 Dec 2008

Mead Simon, Poulter Mark, Beck John, Uphill James, Jones Chris, Ang Cheng Eng, Mein Charles A, Collinge John

Abstract excerpt

Highly accurate and high-throughput SNP genotyping platforms are increasingly popular but the performance of suboptimal DNA samples remains unclear. The aim of our study was to determine the best platform, amplification technique, and loading concentration to maximize genotype accuracy and call rate using degraded samples. We amplified high-molecular weight genomic DNA samples recently extracted from whole blood...

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PMID: 18551557
DOI: 10.1002/humu.20782

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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