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Article

Targeted deletion of SAP1 abolishes the expression of infectivity factors necessary for successful malaria parasite liver infection.

Molecular microbiology - 1 Jul 2008

Aly Ahmed S I, Mikolajczak Sebastian A, Rivera Hilda Silva, Camargo Nelly, Jacobs-Lorena Vanessa, Labaied Mehdi, Coppens Isabelle, Kappe Stefan H I

Abstract excerpt

Malaria parasite sporozoites prepare for transmission to a mammalian host by upregulation of UIS (Upregulated in Infectious Sporozoites) genes. A number of UIS gene products are essential for the establishment of the intrahepatocytic niche. However, the factors that regulate the expression of genes involved in gain of infectivity for the liver are unknown. Herein, we show that a conserved Plasmodium sporozoite...

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Identifiers

PMID: 18466298
DOI: 10.1111/j.1365-2958.2008.06271.x
PMCID: PMC2615191

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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