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Plasmodium Protease ROM1 Is Important for Proper Formation of the Parasitophorous Vacuole

1 Sept 2011

Abstract excerpt

Apicomplexans are obligate intracellular parasites that invade host cells by an active process leading to the formation of a non-fusogenic parasitophorous vacuole (PV) where the parasite replicates within the host cell. The rhomboid family of proteases cleaves substrates within their transmembrane domains and has been implicated in the invasion process. Although its exact function is unknown, Plasmodium ROM1 is...

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PMID: 21909259
DOI: 10.1371/journal.ppat.1002197

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