Article
Role of Plasmodium berghei cGMP-dependent protein kinase in late liver stage development.
The Journal of biological chemistry - 29 Jan 2010
Falae Adebola, Combe Audrey, Amaladoss Anburaj, Carvalho Teresa, Menard Robert, Bhanot Purnima
Abstract excerpt
The liver is the first organ infected by Plasmodium sporozoites during malaria infection. In the infected hepatocytes, sporozoites undergo a complex developmental program to eventually generate hepatic merozoites that are released into the bloodstream in membrane-bound vesicles termed merosomes. Parasites blocked at an early developmental stage inside hepatocytes elicit a protective host immune response, making...
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