Two Plasmodium 6-Cys family-related proteins have distinct and critical roles in liver-stage development.

doi:10.1096/fj.13-241570

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Article

Two Plasmodium 6-Cys family-related proteins have distinct and critical roles in liver-stage development.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 May 2014

Annoura Takeshi, van Schaijk Ben C L, Ploemen Ivo H J, Sajid Mohammed, Lin Jing-wen, Vos Martijn W, Dinmohamed Avinash G, Inaoka Daniel K, Rijpma Sanna R, van Gemert Geert-Jan, Chevalley-Maurel Severine, Kiełbasa Szymon M, Scheltinga Fay, Franke-Fayard Blandine, Klop Onny, Hermsen Cornelus C, Kita Kiyoshi, Gego Audrey, Franetich Jean-Francois, Mazier Dominique, Hoffman Stephen L, Janse Chris J, Sauerwein Robert W, Khan Shahid M

Abstract excerpt

The 10 Plasmodium 6-Cys proteins have critical roles throughout parasite development and are targets for antimalaria vaccination strategies. We analyzed the conserved 6-cysteine domain of this family and show that only the last 4 positionally conserved cysteine residues are diagnostic for this domain and identified 4 additional "6-Cys family-related" proteins. Two of these, sequestrin and B9, are critical to...

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PMID: 24509910
DOI: 10.1096/fj.13-241570

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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