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Article

Characterization of DNA-binding-dependent and -independent functions of SCL/TAL1 during human erythropoiesis.

Blood - 1 May 2004

Ravet Emmanuel, Reynaud Damien, Titeux Monique, Izac Brigitte, Fichelson Serge, Roméo Paul-Henri, Dubart-Kupperschmitt Anne, Pflumio Françoise

Abstract excerpt

The transcription factor TAL1 has major functions during embryonic hematopoiesis and in adult erythropoiesis and megakaryocytopoiesis. These functions rely on different TAL1 structural domains that are responsible for dimerization, transactivation, and DNA binding. Previous work, most often done...

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Share to Antigens, CD34
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Share to Erythroid Precursor Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 14715640
DOI: 10.1182/blood-2003-05-1689

Genes

TAL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-14715640-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Characterization of DNA-binding-dependent and -independent functions of SCL/TAL1 during human erythropoiesis.PMID 14715640Read ↗

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The T cell leukemia oncoprotein SCL/tal-1 is essential for development of all hematopoietic lineages.Semantic proximity Read ↗

Expression of tal-1 and GATA-binding proteins during human hematopoiesisSemantic proximity Read ↗

The hematopoietic regulator TAL1 is required for chromatin looping between the β-globin LCR and human γ-globin genes to activate transcriptionSemantic proximity Read ↗

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Defining the Minimal Factors Required for Erythropoiesis through Direct Lineage ConversionSemantic proximity Read ↗

Ectopic TAL-1/SCL expression in phenotypically normal or leukemic myeloid precursors: proliferative and antiapoptotic effects coupled with a differentiation blockade.Semantic proximity Read ↗

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