Article
Tumor cells can escape DNA-damaging cisplatin through DNA endoreduplication and reversible polyploidy.
Cell biology international - 1 Sept 2008
Puig Pierre-Emmanuel, Guilly Marie-Noëlle, Bouchot André, Droin Nathalie, Cathelin Dominique, Bouyer Florence, Favier Laure, Ghiringhelli François, Kroemer Guido, Solary Eric, Martin François, Chauffert Bruno
Abstract excerpt
Cancer chemotherapy can induce tumor regression followed, in many cases, by relapse in the long-term. Thus this study was performed to assess the determinants of such phenomenon using an in vivo cancer model and in vitro approaches. When animals bearing an established tumor are treated by cisplatin, the tumor initially undergoes a dramatic shrinkage and is characterized by giant tumor cells that do not...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.