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Polyploid giant cancer cells and ovarian cancer: new insights into mitotic regulators and polyploidy

25 May 2021

Abstract excerpt

Current first-line treatment of patients with high-grade serous ovarian cancer (HGSOC) involves the use of cytotoxic drugs that frequently lead to recurrent tumors exhibiting increased resistance to the drugs and poor patient survival. Strong evidence is accumulating to show that HGSOC tumors and cell lines contain a subset of cells called polyploidy giant cancer cells (PGCCs) that act as stem-like, self-renewing...

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PMID: 34037700
DOI: 10.1093/biolre/ioab102

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