Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Senescence in polyploid giant cancer cells: A road that leads to chemoresistance.

Cytokine & growth factor reviews - 1 Apr 2020

Bharadwaj Deblina, Mandal Mahitosh

Abstract excerpt

Cellular senescence has been associated with age-related diseases, wound healing, fibrosis, diabetes and cancer. Senescent cells lack the capacity to proliferate, but are known to aggravate tumorigenesis. The polyploid giant cells arise from the cancer cell population mainly due to genotoxic stress caused by chemotherapy and/or radiotherapy. They exhibit features of senescence and have been reported to secrete an...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Polyploidy
Share to Carcinogenesis
Share to Cell Transformation, Neoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cellular Senescence

Share to Drug Resistance, Neoplasm

Share to Giant Cells

Share to Intercellular Signaling Peptides and Proteins

Share to Tumor Microenvironment

Source

Identifiers

PMID: 31780423
DOI: 10.1016/j.cytogfr.2019.11.002

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Senescence in polyploid giant cancer cells: A road that leads to chemoresistance.PMID 31780423Read ↗

Human cell polyploidization: The good and the evilSemantic proximity Read ↗

A multi-stage process including transient polyploidization and EMT precedes the emergence of chemoresistent ovarian carcinoma cells with a dedifferentiated and pro-inflammatory secretory phenotypeSemantic proximity Read ↗

Giant Multinucleated Cells in Aging and Senescence—An AbridgementSemantic proximity Read ↗

Roles of Polyploid/Multinucleated Giant Cancer Cells in Metastasis and Disease Relapse Following Anticancer TreatmentSemantic proximity Read ↗

Dormant cancer cells and polyploid giant cancer cells: The roots of cancer recurrence and metastasisSemantic proximity Read ↗

Understanding Polyploid Giant Cancer Cells: From Molecular Mechanisms to Clinical ImplicationsSemantic proximity Read ↗

Polyploid Giant Cancer Cells (PGCCs): The Evil Roots of CancerSemantic proximity Read ↗

Recent advancement of autophagy in polyploid giant cancer cells and its interconnection with senescence and stemness for therapeutic opportunitiesSemantic proximity Read ↗

Senescent Cells in Cancer Therapy: Friends or Foes?Semantic proximity Read ↗

Chemotherapy-induced senescence, an adaptive mechanism driving resistance and tumor heterogeneitySemantic proximity Read ↗

Polyploid giant cancer cells and cancer progressionSemantic proximity Read ↗

The life cycle of polyploid giant cancer cells and dormancy in cancer: Opportunities for novel therapeutic interventionsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.