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Article

Neosis: A Novel Type of Cell Division in Cancer

2 Feb 2004

Abstract excerpt

Using computerized video time-lapse microscopy, we studied early cellular events during carcinogen-induced transformation of C3H10T1/2 cells. Multinucleate/polyploid giant cells (MN/PGs) formed due to DNA damage are thought to die via mitotic catastrophe. Before they die, some MN/PGs undergo a novel type of cell division, termed neosis, characterized by karyokinesis via nuclear budding followed by asymmetric,...

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PMID: 14726689
DOI: 10.4161/cbt.3.2.663

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