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Article

RNA stability regulates differential expression of the metastasis protein, osteopontin, in hepatocellular cancer.

Surgery - 1 Jun 2008

Emani Sirisha, Zhang Jinping, Guo Lucie, Guo Hongtao, Kuo Paul C

Abstract excerpt

BACKGROUND: Osteopontin (OPN) is a potential therapeutic target in hepatocellular carcinoma (HCC), because it is a critical mediator of metastatic function. The molecular mechanisms that determine expression of OPN in HCC, however, are unknown. In this study, we examine differential OPN expression in the 2 HCC cell lines: HepG2 and Hep3B. METHODS: OPN expression, metastatic function, OPN promoter activity, and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 18549897
DOI: 10.1016/j.surg.2008.02.005
PMCID: PMC2494577

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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