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Article

Micro-RNA-181a regulates osteopontin-dependent metastatic function in hepatocellular cancer cell lines.

Surgery - 1 Aug 2010

Bhattacharya Syamal D, Garrison Juline, Guo Hongtao, Mi Zhiyong, Markovic Jovan, Kim Victoria M, Kuo Paul C

Abstract excerpt

BACKGROUND: Osteopontin (OPN) is a variably expressed, secreted glycophosphoprotein that mediates the growth and metastases of hepatocellular cancer (HCC). MicroRNAs (miRNAs) may be responsible for variant OPN expression, interrupting translation by binding OPN messenger RNA (mRNA) in 3'-untranslated regions (UTRs). METHODS: A microarray analysis identified miRNAs of interest. Plasmid constructs using a...

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Identifiers

PMID: 20576283
DOI: 10.1016/j.surg.2010.05.007
PMCID: PMC2905491

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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