Article
Identification of tristetraprolin as a factor that modulates the stability of the TAFI transcript through binding to the 3'-untranslated region.
Journal of thrombosis and haemostasis : JTH - 1 May 2012
Novakovic D, Kuo A C Y, Lin J H, Koschinsky M L, Boffa M B
Abstract excerpt
BACKGROUND: Thrombin-activatable fibrinolysis inhibitor (TAFI) is a basic carboxypeptidase zymogen encoded by the human gene CPB2. TAFI constitutes a molecular link between coagulation and fibrinolysis, and between coagulation and inflammation. The 3'-untranslated region (UTR) of the human CPB2 mRNA plays a key role in regulating CPB2 mRNA abundance, but the exact mechanisms that mediate this regulation are...
Topics
- 3' Untranslated Regions
- Animals
- Base Sequence
- Beta-Globulins
- Binding Sites
- Carboxypeptidase B2
- Electrophoretic Mobility Shift Assay
- Hep G2 Cells
- Humans
- Molecular Sequence Data
- Mutagenesis, Site-Directed
- Mutation
- RNA Interference
- RNA Stability