Article
The human prion gene M129V polymorphism is not associated with idiopathic Parkinson's disease in three distinct populations.
Neuroscience letters - 13 Mar 2006
Scholz Sonja W, Xiromerisiou Georgia, Fung Hon C, Eerola Johanna, Hellström Olli, Papadimitriou Alexandros, Hadjigeorgiou Georgios M, Tienari Pentti J, Fernandez Hubert H, Mandel Ronald, Okun Michael S, Gwinn-Hardy Katharina, Singleton Andrew B
Abstract excerpt
Coexistence of prion disease and idiopathic Parkinson's disease (IPD) has been previously described. It remains unclear whether this relationship may reflect the high incidence of IPD or whether both prion and IPD share common pathogenetic mechanisms. For this reason, we investigated the genotype distribution of the M129V polymorphism of the human prion gene for association with IPD (controls: n = 398, IPD cases:...
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