Article
Methionine homozygosity at codon 129 in the prion protein is associated with white matter reduction and enlargement of CSF compartments in healthy volunteers and schizophrenic patients.
NeuroImage - 1 Jan 2002
Rujescu D, Meisenzahl E M, Giegling I, Kirner A, Leinsinger G, Hegerl U, Hahn K, Möller H-J
Abstract excerpt
Twin studies point toward a substantial heritability in individual variations in the size of the human brain. However, the etiology is largely unknown. The prion protein (gene name: PRNP) aids cellular resistance to oxidative stress and neurodegeneration and is involved in neurodevelopment. This study examines the influence of a polymorphism in the PRNP gene on brain morphology in 47 healthy males and 43 male...
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