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An improved method for generating BAC DNA suitable for FISH

1 Jan 2008

Abstract excerpt

Fluorescence in situ hybridization (FISH) is commonly used to identify chromosomal aberrations such as translocations, deletions, duplications, gene fusions, and aneuploidies. It relies on the hybridization of fluorescently labeled DNA probes onto denatured metaphase chromosomes or interphase nuclei. These probes are often generated from DNA sequences cloned within bacterial artificial chromosomes (BACs). Growing...

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PMID: 18544919
DOI: 10.1159/000124374

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