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Article

Thr105Ile, a functional polymorphism of histamine N-methyltransferase, is associated with alcoholism in two independent populations.

Alcoholism, clinical and experimental research - 1 Mar 2005

Oroszi Gabor, Enoch Mary-Anne, Chun Jeffrey, Virkkunen Matti, Goldman David

Abstract excerpt

BACKGROUND: Histamine is expressed in cortical and limbic areas that are involved in emotion and cognition and modulates these behaviors. H1 receptor antagonists are sedative. Histamine N-methyltransferase (HNMT) catalyzes the Ntau methylation of histamine, the sole pathway for termination of the neurotransmitter action of histamine in mammalian brain. A common and functionally significant polymorphism, a C314T...

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Source

Identifiers

PMID: 15770103
DOI: 10.1097/01.alc.0000156128.28257.2e

Genes

HNMT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Thr105Ile, a functional polymorphism of histamine N-methyltransferase, is associated with alcoholism in two independent populations.PMID 15770103Read ↗

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