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Article

Association of an orexin 1 receptor 408Val variant with polydipsia-hyponatremia in schizophrenic subjects.

Biological psychiatry - 1 Sept 2005

Meerabux Joanne, Iwayama Yoshimi, Sakurai Takeshi, Ohba Hisako, Toyota Tomoko, Yamada Kazuo, Nagata Ruby, Irukayama-Tomobe Yoko, Shimizu Hiromitsu, Yoshitsugu Kiyoshi, Ohta Katsuya, Yoshikawa Takeo

Abstract excerpt

BACKGROUND: Primary polydipsia is a common complication in patients with chronic psychoses, particularly schizophrenia. Disease pathogenesis is poorly understood, but one contributory factor is thought to be dopamine dysregulation caused by prolonged treatment with neuroleptics. Both angiotensin-converting enzyme (ACE) and orexin (hypocretin) signaling can modulate drinking behavior through interactions with the...

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Source

Identifiers

PMID: 15978554
DOI: 10.1016/j.biopsych.2005.04.015

Genes

ACE
HCRTR1
HCRT
HCRTR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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