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Article

The orexin 1 receptor (HCRTR1) gene as a susceptibility gene contributing to polydipsia-hyponatremia in schizophrenia.

Neuromolecular medicine - 1 Jan 2007

Fukunaka Yuko, Shinkai Takahiro, Hwang Rudi, Hori Hiroko, Utsunomiya Kensuke, Sakata Shinichi, Naoe Yui, Shimizu Kazuko, Matsumoto Chima, Ohmori Osamu, Nakamura Jun

Abstract excerpt

The underlying pathophysiology of primary polydipsia in schizophrenia (SCZ) is poorly understood. Our previous study, however, suggested that this condition may have a genetic component [Shinkai et al 2003 Am J Med Genet 119B 7-12]. Orexins, also called hypocretins, play an important role in feeding and drinking behavior. Administration of orexin in rats has been shown to induce increased water intake with a...

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Identifiers

PMID: 17999203
DOI: 10.1007/s12017-007-8001-2

Genes

HCRTR1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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