Article
The genetics of multiple sclerosis: SNPs to pathways to pathogenesis.
Nature reviews. Genetics - 1 Jul 2008
Oksenberg Jorge R, Baranzini Sergio E, Sawcer Stephen, Hauser Stephen L
Abstract excerpt
Multiple sclerosis (MS) is an autoimmune demyelinating disease and a common cause of neurological disability in young adults. The modest heritability of MS reflects complex genetic effects and multifaceted gene-environment interactions. The human leukocyte antigen (HLA) region is the strongest susceptibility locus for MS, but a genome-wide association study recently identified new susceptibility genes. Progress...
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