Article
Peroxisome proliferator-activated receptor [alpha] genetic variation interacts with n-6 and long-chain n-3 fatty acid intake to affect total cholesterol and LDL-cholesterol concentrations in the Atherosclerosis Risk in Communities Study.
The American journal of clinical nutrition - 1 Jun 2008
Volcik Kelly A, Nettleton Jennifer A, Ballantyne Christie M, Boerwinkle Eric
Abstract excerpt
BACKGROUND: Peroxisome proliferator-activated receptor-alpha (PPARA) regulates the expression of genes involved in lipid metabolism. The binding of polyunsaturated fatty acids (PUFAs) to PPARA results in rapid changes in the expression of genes involved in lipid oxidation, with long-chain n-3 fatty acids being potent activators of PPARA. OBJECTIVE: We evaluated the potential effect modification of PPARA genetic...
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