Article
Association analysis between functional polymorphism of the rs4606 SNP in the RGS2 gene and antipsychotic-induced Parkinsonism in Japanese patients with schizophrenia: results from the Juntendo University Schizophrenia Projects (JUSP).
Neuroscience letters - 18 Jan 2010
Higa Masayuki, Ohnuma Tohru, Maeshima Hitoshi, Hatano Tokiko, Hanzawa Ryo, Shibata Nobuto, Sakai Yoshie, Suzuki Toshihito, Arai Heii
Abstract excerpt
Antipsychotic-induced extrapyramidal symptoms (AIEPSs) are commonly recognized side effects of typical 1st generation antipsychotics, and considerable variability is seen in the susceptibility of individual patients to AIEPSs. Regulator of G-protein signaling 2 (RGS2) proteins regulate intracellular signaling and second messenger activation of molecules including dopamine, serotonin, and acetylcholine receptors,...
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