Article
The Pro12Ala polymorphism of peroxisome proliferator-activated receptor-gamma2 gene is associated with plasma levels of soluble RAGE (Receptor for Advanced Glycation Endproducts) and the presence of peripheral arterial disease.
Clinical biochemistry - 1 Aug 2008
Catalano Mariella, Cortelazzo Adriano, Santi Roberto, Contino Laura, Demicheli Marta, Yilmaz Yusuf, Zorzetto Michele, Campo Ilaria, Lanati Niccolò, Emanuele Enzo
Abstract excerpt
OBJECTIVES: Recent evidences suggest that the activation of peroxisome proliferator-activated receptor (PPAR)-gamma2, which plays an important role in vascular homeostasis, also regulates the expression of the Receptor for Advanced Glycation End products (RAGE). In turn, low levels of soluble RAGE (sRAGE) have recently emerged as a valuable biomarker of vascular inflammation. The potential alterations in sRAGE...
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