Article
Homozygosity for the Ala allele of the PPARγ2 Pro12Ala polymorphism is associated with reduced risk of coronary artery disease.
Disease markers - 1 Jan 2010
Galgani Andrea, Valdes AnaMaria, Erlich Henry A, Mano Calvin, Cheng Suzanne, Petrone Antonio, Sentinelli Federica, Berni Andrea, Baroni Marco G, Buzzetti Raffaella
Abstract excerpt
Several studies suggest that the peroxisome proliferator-activated receptor gamma (PPARγ) is involved in atherogenesis. The Pro12Ala polymorphism in the gene encoding PPARγ (PPARγ2 gene) influences the risk for type 2 diabetes. Two population-based studies have shown that the Ala allele is associated with reduced carotid intimal-medial thickness (IMT). However, studies focusing on acute clinical events have...
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