The human peroxisome proliferator-activated receptor gamma2 (PPARgamma2) Pro12Ala polymorphism is associated with decreased risk of diabetic nephropathy in patients with type 2 diabetes.

doi:10.2337/diabetes.52.12.3010

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The human peroxisome proliferator-activated receptor gamma2 (PPARgamma2) Pro12Ala polymorphism is associated with decreased risk of diabetic nephropathy in patients with type 2 diabetes.

Diabetes - 1 Dec 2003

Caramori Maria Luiza, Canani Luis Henrique, Costa Luciana A, Gross Jorge Luiz

Abstract excerpt

The peroxisome proliferator-activated receptor gamma2 (PPARgamma2) Pro12Ala polymorphism has been associated with a decreased risk of type 2 diabetes and a lower albumin excretion rate (AER) in patients with established diabetes. We performed a case-control study aiming to evaluate the association between the Pro12Ala polymorphism and diabetic nephropathy. Genomic DNA was obtained from 104 type 2 diabetic...

Topics

Aged
Alanine
Case-Control Studies
Diabetes Mellitus, Type 2
Diabetic Nephropathies
Female
Gene Frequency
Genetic Predisposition to Disease
Heterozygote
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Middle Aged

Odds Ratio

Polymorphism, Genetic

Receptors, Cytoplasmic and Nuclear

Transcription Factors

Source

Open in PubMed

Identifiers

PMID: 14633865
DOI: 10.2337/diabetes.52.12.3010

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