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Article

Ala12Ala genotype of the peroxisome proliferator-activated receptor gamma2 protects against atherosclerosis.

The Journal of clinical endocrinology and metabolism - 1 Sept 2004

Temelkova-Kurktschiev Theodora, Hanefeld Markolf, Chinetti Giulia, Zawadzki Christophe, Haulon Stephan, Kubaszek Agata, Koehler Carsta, Leonhardt Wolfgang, Staels Bart, Laakso Markku

Abstract excerpt

A mutation in the peroxisome proliferator-activated receptor gamma2 (PPARgamma2) gene with a cytosine to guanine substitution results in an exchange of proline (Pro) with alanine (Ala) in exon B (codon 12) of this gene. This polymorphism has been associated with high insulin sensitivity and low body weight, but no data have been published to date about its effect on early atherosclerosis. We investigated the...

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Source

Identifiers

PMID: 15356014
DOI: 10.1210/jc.2003-032120

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Ala12Ala genotype of the peroxisome proliferator-activated receptor gamma2 protects against atherosclerosis.PMID 15356014Read ↗

Homozygosity for the Ala allele of the PPARγ2 Pro12Ala polymorphism is associated with reduced risk of coronary artery disease.Semantic proximity Read ↗

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The Peroxisome Proliferator-Activated Receptor-γ2 Pro12Ala PolymorphismSemantic proximity Read ↗

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The association of Pro12Ala polymorphism in PPARgamma2 with lower carotid artery IMT in Japanese.Semantic proximity Read ↗

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