Article
Identification of BRCA1/2 founder mutations in Southern Chinese breast cancer patients using gene sequencing and high resolution DNA melting analysis.
PloS one - 1 Jan 2012
Kwong Ava, Ng Enders Kai On, Wong Chris Lei Po, Law Fian Bic Fai, Au Tommy, Wong Hong Nei, Kurian Allison W, West Dee W, Ford James M, Ma Edmond Siu Kwan
Abstract excerpt
BACKGROUND: Ethnic variations in breast cancer epidemiology and genetics have necessitated investigation of the spectra of BRCA1 and BRCA2 mutations in different populations. Knowledge of BRCA mutations in Chinese populations is still largely unknown. We conducted a multi-center study to characterize the spectra of BRCA mutations in Chinese breast and ovarian cancer patients from Southern China....
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