Article
Impaired embryonic haematopoiesis yet normal arterial development in the absence of the Notch ligand Jagged1.
The EMBO journal - 9 Jul 2008
Robert-Moreno Alex, Guiu Jordi, Ruiz-Herguido Cristina, López M Eugenia, Inglés-Esteve Julia, Riera Lluis, Tipping Alex, Enver Tariq, Dzierzak Elaine, Gridley Thomas, Espinosa Lluis, Bigas Anna
Abstract excerpt
Specific deletion of Notch1 and RBPjkappa in the mouse results in abrogation of definitive haematopoiesis concomitant with the loss of arterial identity at embryonic stage. As prior arterial determination is likely to be required for the generation of embryonic haematopoiesis, it is difficult to establish the specific haematopoietic role of Notch in these mutants. By analysing different Notch-ligand-null embryos,...
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