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Article

Effects of active and inactive phospholipase D2 on signal transduction, adhesion, migration, invasion, and metastasis in EL4 lymphoma cells.

Molecular pharmacology - 1 Sept 2008

Knoepp Stewart M, Chahal Manpreet S, Xie Yuhuan, Zhang Zhihong, Brauner Daniel J, Hallman Mark A, Robinson Stephanie A, Han Shujie, Imai Masaki, Tomlinson Stephen, Meier Kathryn E

Abstract excerpt

The phosphatidylcholine-using phospholipase D (PLD) isoform PLD2 is widely expressed in mammalian cells and is activated in response to a variety of promitogenic agonists. In this study, active and inactive hemagglutinin-tagged human PLD2 (HA-PLD2) constructs were stably expressed in an EL4 cell line lacking detectable endogenous PLD1 or PLD2. The overall goal of the study was to examine the roles of PLD2 in...

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Share to Cell Adhesion
Share to Extracellular Signal-Regulated MAP Kinases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Focal Adhesion Protein-Tyrosine Kinases

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Share to Neoplasm Invasiveness

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Share to Proto-Oncogene Proteins c-akt

Source

Identifiers

PMID: 18523140
DOI: 10.1124/mol.107.040105

Genes

PLD2
PLD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Effects of active and inactive phospholipase D2 on signal transduction, adhesion, migration, invasion, and metastasis in EL4 lymphoma cells.PMID 18523140Read ↗

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