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Article

Down-regulation of MicroRNAs (MiRs) 203, 887, 3619 and 182 Prevents Vimentin-triggered, Phospholipase D (PLD)-mediated Cancer Cell Invasion.

The Journal of biological chemistry - 8 Jan 2016

Fite Kristen, Gomez-Cambronero Julian

Abstract excerpt

Breast cancer is a leading cause of morbidity and mortality among women. Metastasis is initiated after epithelial-mesenchymal-transition (EMT). We have found a connection between EMT markers and the expression of four microRNAs (miRs) mediated by the signaling enzyme phospholipase D (PLD). Low aggressive MCF-7 breast cancer cells have low endogenous PLD enzymatic activity and cell invasion, concomitant with high...

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Identifiers

PMID: 26567912
DOI: 10.1074/jbc.M115.686006
PMCID: PMC4705392

Genes

PLD1
PLD2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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Down-regulation of MicroRNAs (MiRs) 203, 887, 3619 and 182 Prevents Vimentin-triggered, Phospholipase D (PLD)-mediated Cancer Cell Invasion.PMID 26567912Read ↗

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