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Article

Activation and block of the adult muscle-type nicotinic receptor by physostigmine: single-channel studies.

Molecular pharmacology - 1 Sept 2008

Militante Julius, Ma Bei-Wen, Akk Gustav, Steinbach Joe Henry

Abstract excerpt

The plant-derived acetylcholinesterase inhibitor physostigmine has previously been shown to act on the nicotinic acetylcholine receptor (nAChR) causing either direct activation or potentiation of currents elicited by low concentrations of nicotinic agonists, or, at higher concentrations, channel block. We examined mouse adult-type muscle nAChR activation by physostigmine and found that channel activation by...

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Identifiers

PMID: 18523135
DOI: 10.1124/mol.108.047134
PMCID: PMC2536770

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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