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Article

Dedicated metallochaperone connects apoenzyme and molybdenum cofactor biosynthesis components.

The Journal of biological chemistry - 1 Aug 2008

Genest Olivier, Neumann Meina, Seduk Farida, Stöcklein Walter, Méjean Vincent, Leimkühler Silke, Iobbi-Nivol Chantal

Abstract excerpt

The biogenesis of molybdenum-containing enzymes is a sophisticated process involving the insertion of a complex molybdenum cofactor into competent apoproteins. As for many molybdoenzymes, the maturation of trimethylamine-oxide reductase TorA requires a private chaperone. This chaperone (TorD) interacts with the signal peptide and the core of apo-TorA. Using random mutagenesis, we established that alpha-helix 5 of...

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PMID: 18522945
DOI: 10.1074/jbc.M802954200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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