Article
A novel and ubiquitous system for membrane targeting and secretion of cofactor-containing proteins.
Cell - 3 Apr 1998
Weiner J H, Bilous P T, Shaw G M, Lubitz S P, Frost L, Thomas G H, Cole J A, Turner R J
Abstract excerpt
We report the identification of the proteins encoded by the mttABC operon (formerly yigTUW), which mediate a novel Sec-independent membrane targeting and translocation system in Escherichia coli that interacts with cofactor-containing redox proteins having a S/TRRXFLK "twin arginine" leader motif. A pleiotropic-negative mutant in mttA prevents the periplasmic localization of twin arginine redox enzymes, including...
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