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Article

Biochemical and structural analysis of the molybdenum cofactor biosynthesis protein MobA.

The Journal of biological chemistry - 11 Jul 2003

Guse Annika, Stevenson Clare E M, Kuper Jochen, Buchanan Grant, Schwarz Gunter, Giordano Gerard, Magalon Axel, Mendel Ralf R, Lawson David M, Palmer Tracy

Abstract excerpt

Molybdopterin guanine dinucleotide (MGD) is the form of the molybdenum cofactor that is required for the activity of most bacterial molybdoenzymes. MGD is synthesized from molybdopterin (MPT) and GTP in a reaction catalyzed by the MobA protein. Here we report that wild type MobA can be copurified along with bound MPT and MGD, demonstrating a tight binding of both its substrate and product. To study...

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PMID: 12719427
DOI: 10.1074/jbc.M302639200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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