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Article

Prognostic significance of defective mismatch repair and BRAF V600E in patients with colon cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jun 2008

French Amy J, Sargent Daniel J, Burgart Lawrence J, Foster Nathan R, Kabat Brian F, Goldberg Richard, Shepherd Lois, Windschitl Harold E, Thibodeau Stephen N

Abstract excerpt

PURPOSE: Colon tumors with defective DNA mismatch repair (dMMR) have a well-characterized phenotype and accounts for approximately 15% to 20% of sporadic colon cancer as well as those colon cancer patients with Lynch syndrome. Although the presence of dMMR seems to be a favorable prognostic marker, data suggest that these patients do not respond as well to adjuvant chemotherapy. EXPERIMENTAL DESIGN: In this...

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Identifiers

PMID: 18519771
DOI: 10.1158/1078-0432.CCR-07-1489
PMCID: PMC2674786

Genes

BRAF

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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