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Article

Molecular markers identify subtypes of stage III colon cancer associated with patient outcomes.

Gastroenterology - 1 Jan 2015

Sinicrope Frank A, Shi Qian, Smyrk Thomas C, Thibodeau Stephen N, Dienstmann Rodrigo, Guinney Justin, Bot Brian M, Tejpar Sabine, Delorenzi Mauro, Goldberg Richard M, Mahoney Michelle, Sargent Daniel J, Alberts Steven R

Abstract excerpt

BACKGROUND & AIMS: Categorization of colon cancers into distinct subtypes using a combination of pathway-based biomarkers could provide insight into stage-independent variability in outcomes. METHODS: We used a polymerase chain reaction-based assay to detect mutations in BRAF (V600E) and in KRAS in 2720 stage III cancer samples, collected prospectively from patients participating in an adjuvant chemotherapy trial...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25305506
DOI: 10.1053/j.gastro.2014.09.041
PMCID: PMC4274188

Genes

BRAF
KRAS
MLH1
MSH2
MSH6

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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