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Article

Parkin analysis in early onset Parkinson's disease.

Parkinsonism & related disorders - 1 Jan 2008

Sironi Francesca, Primignani Paola, Zini Michela, Tunesi Sara, Ruffmann Claudio, Ricca Sara, Brambilla Tiziana, Antonini Angelo, Tesei Silvana, Canesi Margherita, Zecchinelli Anna, Mariani Claudio, Meucci Nicoletta, Sacilotto Giorgio, Cilia Roberto, Isaias Ioannis U, Garavaglia Barbara, Ghezzi Daniele, Travi Maurizio, Decarli Adriano, Coviello Domenico A, Pezzoli Gianni, Goldwurm Stefano

Abstract excerpt

We analysed the parkin gene in a large consecutive series (146) of unrelated early onset Parkinson's disease (onset ?40 years of age) patients. Twelve cases (8.2%) had homozygous or compound heterozygous point mutations and/or exon rearrangements, while a single mutation was found in four subjects (2.7%). We identified eight exon rearrangements and nine point mutations, two of which were novel: c.735delT...

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PMID: 18519021
DOI: 10.1016/j.parkreldis.2007.10.003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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