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Article

Role of parkin mutations in 111 community-based patients with early-onset parkinsonism.

Annals of neurology - 1 May 2002

Kann Martin, Jacobs Helfried, Mohrmann Kathrin, Schumacher Kirsten, Hedrich Katja, Garrels Jennifer, Wiegers Karin, Schwinger Eberhard, Pramstaller Peter P, Breakefield Xandra O, Ozelius Laurie J, Vieregge Peter, Klein Christine

Abstract excerpt

Early-onset parkinsonism is frequently reported in connection with mutations in the parkin gene. In this study, we present the results of extensive genetic screening for parkin mutations in 111 community-derived early-onset parkinsonism patients (age of onset <50 years) from Germany with an overall mutation rate of 9.0%. Gene dosage alterations represented 67% of the mutations found, underlining the importance of...

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PMID: 12112109
DOI: 10.1002/ana.10179

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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