Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Parkin (PARK 2) mutations are rare in Czech patients with early-onset Parkinson's disease.

PloS one - 1 Jan 2014

Fiala Ondrej, Zahorakova Daniela, Pospisilova Lenka, Kucerova Jana, Matejckova Milada, Martasek Pavel, Roth Jan, Ruzicka Evzen

Abstract excerpt

OBJECTIVE: The aim of the study is to determine the frequency of parkin allelic variants in Czech early-onset Parkinson's disease patients and healthy controls. METHODS: A total of 70 early-onset Parkinson's disease patients (age at onset ≤40 years) and 75 controls were screened for the sequence variants and exon rearrangements in the parkin gene. RESULTS: Parkin mutations were identified in five patients (7.1%):...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Age Factors
Share to Czech Republic

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genotype

Share to Mutation

Share to Parkinson Disease

Share to Sequence Deletion

Share to Ubiquitin-Protein Ligases

Source

Open in PubMed Open full text

Identifiers

PMID: 25238391
DOI: 10.1371/journal.pone.0107585
PMCID: PMC4169530

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Parkin (PARK 2) mutations are rare in Czech patients with early-onset Parkinson's disease.PMID 25238391Read ↗

Parkin mutations and phenotypic features in Czech patients with early-onset Parkinson's disease.Semantic proximity Read ↗

Low frequency of the PARK2 gene mutations in Polish patients with the early-onset form of Parkinson disease.Semantic proximity Read ↗

A wide variety of mutations in the parkin gene are responsible for autosomal recessive parkinsonism in Europe. French Parkinson's Disease Genetics Study Group and the European Consortium on Genetic Susceptibility in Parkinson's Disease.Semantic proximity Read ↗

Rare heterozygous parkin variants in French early-onset Parkinson disease patients and controlsSemantic proximity Read ↗

Novel parkin mutations detected in patients with early-onset Parkinson's disease.Semantic proximity Read ↗

Genetic analysis of PARK2 and PINK1 genes in Brazilian patients with early-onset Parkinson's disease.Semantic proximity Read ↗

Case-control study of the parkin gene in early-onset Parkinson disease.Semantic proximity Read ↗

Incidence of mutations in the PARK2, PINK1, PARK7 genes in Polish early-onset Parkinson disease patients.Semantic proximity Read ↗

Parkin gene variations in late-onset Parkinson's disease: comparison between Norwegian and German cohorts.Semantic proximity Read ↗

Parkin analysis in early onset Parkinson's disease.Semantic proximity Read ↗

parkin mutation analysis in clinic patients with early-onset Parkinson [corrected] disease.Semantic proximity Read ↗

Parkin and PINK1 mutations in early-onset Parkinson's disease: comprehensive screening in publicly available cases and control.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.