Article
Genetic analysis of PARK2 and PINK1 genes in Brazilian patients with early-onset Parkinson's disease.
Disease markers - 1 Jan 2013
Moura Karla Cristina Vasconcelos, Campos Junior Mário, de Rosso Ana Lúcia Zuma, Nicaretta Denise Hack, Pereira João Santos, Silva Delson José, dos Santos Flávia Lima, Rodrigues Fabíola da Costa, Santos-Rebouças Cíntia Barros, Pimentel Márcia Mattos Gonçalves
Abstract excerpt
Parkinson's disease is the second most frequent neurodegenerative disorder in the world, affecting 1-2% of individuals over the age of 65. The etiology of Parkinson's disease is complex, with the involvement of gene-environment interactions. Although it is considered a disease of late manifestation, early-onset forms of parkinsonism contribute to 5-10% of all cases. In the present study, we screened mutations in...
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