Article
Parkin mutations are frequent in patients with isolated early-onset parkinsonism.
Brain : a journal of neurology - 1 Jun 2003
Periquet Magali, Latouche Morwena, Lohmann Ebba, Rawal Nina, De Michele Giuseppe, Ricard Sylvain, Teive Hélio, Fraix Valérie, Vidailhet Marie, Nicholl David, Barone Paolo, Wood Nick W, Raskin Salmo, Deleuze Jean-François, Agid Yves, Dürr Alexandra, Brice Alexis
Abstract excerpt
Parkin gene mutations are reported to be a major cause of early-onset parkinsonism (age at onset < or = 45 years) in families with autosomal recessive inheritance and in isolated juvenile-onset parkinsonism (age at onset <20 years). However, the precise frequency of parkin mutations in isolated cases is not known. In order to evaluate the frequency of parkin mutations in patients with isolated early-onset...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.