Article
Association between early-onset Parkinson's disease and mutations in the parkin gene.
The New England journal of medicine - 25 May 2000
Lücking C B, Dürr A, Bonifati V, Vaughan J, De Michele G, Gasser T, Harhangi B S, Meco G, Denèfle P, Wood N W, Agid Y, Brice A
Abstract excerpt
BACKGROUND: Mutations in the parkin gene have recently been identified in patients with early-onset Parkinson's disease, but the frequency of the mutations and the associated phenotype have not been assessed in a large series of patients. METHODS: We studied 73 families in which at least one of the affected family members was affected at or before the age of 45 years and had parents who were not affected, as well...
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