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Article

SV40 T-antigen is required for maintenance of immortal growth in SV40-transformed human fibroblasts.

Cell structure and function - 1 Feb 1991

Tsuyama N, Miura M, Kitahira M, Ishibashi S, Ide T

Abstract excerpt

Two lines of immortal human fibroblasts were isolated following transfection of TIG-3 cells with plasmid DNA, pMT-1ODtsA, that contained SV40 early gene with a deletion in replication origin and ts mutation in coding sequence for T-antigen. These cells continued proliferation at 34 degrees C, over 565 population doubling level (PDL) which is far over the limited division potential of untransformed normal TIG-3 of...

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Identifiers

PMID: 1851674
DOI: 10.1247/csf.16.55

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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