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Article

Neutralization of a negative charge in the S1-S2 region of the KV7.2 (KCNQ2) channel affects voltage-dependent activation in neonatal epilepsy.

The Journal of physiology - 15 Jan 2008

Wuttke Thomas V, Penzien Johann, Fauler Michael, Seebohm Guiscard, Lehmann-Horn Frank, Lerche Holger, Jurkat-Rott Karin

Abstract excerpt

The voltage-gated potassium channels KV7.2 and KV7.3 (genes KCNQ2 and KCNQ3) constitute a major component of the M-current controlling the firing rate in many neurons. Mutations within these two channel subunits cause benign familial neonatal convulsions (BFNC). Here we identified a novel BFNC-causing mutation (E119G) in the S1-S2 region of KV7.2. Electrophysiological investigations in Xenopus oocytes using...

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Source

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Identifiers

PMID: 18006581
DOI: 10.1113/jphysiol.2007.143826
PMCID: PMC2375582

Genes

KCNQ2
KCNQ3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Neutralization of a negative charge in the S1-S2 region of the KV7.2 (KCNQ2) channel affects voltage-dependent activation in neonatal epilepsy.PMID 18006581Read ↗

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