Article
Homocysteine plasma levels in patients treated with antiepileptic drugs depend on folate and vitamin B12 serum levels, but not on genetic variants of homocysteine metabolism.
Clinical chemistry and laboratory medicine - 1 Mar 2013
Semmler Alexander, Moskau-Hartmann Susanna, Stoffel-Wagner Birgit, Elger Christian, Linnebank Michael
Abstract excerpt
BACKGROUND: Antiepileptic drugs (AEDs) are commonly used in the treatment of epilepsy, psychiatric diseases and pain disorders. Several of these drugs influence blood levels of folate and vitamin B12 and, consequently, homocysteine. This may be relevant for AED effects and side effects. However, not only folate and vitamin B12, but also genetic variants modify homocysteine metabolism. Here, we aimed to determine...
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