Article
Parkinson patient fibroblasts show increased alpha-synuclein expression.
Experimental neurology - 1 Aug 2008
Hoepken Hans-Hermann, Gispert Suzana, Azizov Mekhman, Klinkenberg Michael, Ricciardi Filomena, Kurz Alexander, Morales-Gordo Blas, Bonin Michael, Riess Olaf, Gasser Thomas, Kögel Donat, Steinmetz Helmuth, Auburger Georg
Abstract excerpt
Parkinson's disease (PD) is a neurodegenerative movement disorder of advanced age with largely unknown etiology, but well documented tissue damage from oxidative stress. Increased alpha-synuclein (SNCA) expression is known to cause a rare form of PD, early-onset autosomal dominant PARK4. We have previously shown that loss-of-function mutations of the mitochondrial kinase PINK1 which cause the early-onset...
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