Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Microarray expression analysis reveals genetic pathways implicated in C621 synphilin-1-mediated toxicity.

Journal of neural transmission (Vienna, Austria : 1996) - 1 Jul 2008

Bonin M, Marx F P, Kautzmann S, Riess O, Krüger R

Abstract excerpt

Synphilin-1 has been linked to Parkinson's disease (PD) based on its role as an alpha-synuclein (PARK1) and Parkin (PARK2) interacting protein and its presence in lewy bodies in brains of PD patients. We recently identified a R621C mutation in the synphilin-1 gene in German PD patients. Functiona...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Arginine
Share to Carrier Proteins
Share to Cell Line, Transformed

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cysteine

Share to Green Fluorescent Proteins

Share to Nerve Tissue Proteins

Share to Oligonucleotide Array Sequence Analysis

Share to Transforming Growth Factor beta

Source

Identifiers

PMID: 18292964
DOI: 10.1007/s00702-008-0031-x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-18292964-2026-09-04.1. Manifest publication-graph-cohort-2026-09-04.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Microarray expression analysis reveals genetic pathways implicated in C621 synphilin-1-mediated toxicity.PMID 18292964Read ↗

Identification and functional characterization of a novel R621C mutation in the synphilin-1 gene in Parkinson's disease.Semantic proximity Read ↗

Organization of the human synphilin-1 gene, a candidate for Parkinson's disease.Semantic proximity Read ↗

Glycogen synthase kinase 3beta modulates synphilin-1 ubiquitylation and cellular inclusion formation by SIAH: implications for proteasomal function and Lewy body formation.Semantic proximity Read ↗

Microarray analysis of an synthetic α-synuclein induced cellular model reveals the expression profile of long non-coding RNA in Parkinson’s diseaseSemantic proximity Read ↗

MAPKAPK2, a dynamic network biomarker of α-synuclein before its aggregation, was significantly highly expressed in both the brain and peripheral blood of PD patientsSemantic proximity Read ↗

Periphilin is a novel interactor of synphilin-1, a protein implicated in Parkinson's disease.Semantic proximity Read ↗

Transcriptomic analysis of melanoma cells reveals an association of α-synuclein with regulation of the inflammatory responseSemantic proximity Read ↗

Transcriptomic analysis of melanoma cells reveals an association of α-synuclein with regulation of the inflammatory responseSemantic proximity Read ↗

Parkinson patient fibroblasts show increased alpha-synuclein expression.Semantic proximity Read ↗

MAPKAPK2, a potential dynamic network biomarker of α-synuclein prior to its aggregation in PD patientsSemantic proximity Read ↗

Bridging high-throughput genetic and transcriptional data reveals cellular responses to alpha-synuclein toxicitySemantic proximity Read ↗

Analysis of synphilin-1 and synuclein interactions by yeast two-hybrid beta-galactosidase liquid assay.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.