Article
Effect of endogenous mutant and wild-type PINK1 on Parkin in fibroblasts from Parkinson disease patients.
Human molecular genetics - 15 Aug 2010
Rakovic Aleksandar, Grünewald Anne, Seibler Philip, Ramirez Alfredo, Kock Norman, Orolicki Slobodanka, Lohmann Katja, Klein Christine
Abstract excerpt
Mutations in the PTEN-induced putative kinase 1 (PINK1), a mitochondrial serine-threonine kinase, and Parkin, an E3 ubiquitin ligase, are associated with autosomal-recessive forms of Parkinson disease (PD). Both are involved in the maintenance of mitochondrial integrity and protection from multiple stressors. Recently, Parkin was demonstrated to be recruited to impaired mitochondria in a PINK1-dependent manner,...
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