Two thermostable nucleases coexisted in<i>Staphylococcus aureus</i>: evidence from mutagenesis and<i>in vitro</i>expression

Abstract excerpt

Thermostable nuclease is known to be an important pathogenic factor unique to Staphylococcus aureus and it is commonly presumed to have had the same genetic origin. However, two ORFs in S. aureus genomes were predicted to encode nucleases. One encoded an unnamed nuclease A (SNase) (termed nuc1), and the other encoded a thermonuclease (TNase) named nuc (termed nuc2). In order to verify whether the two thermostable...

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